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Case studies and other outcomes (phase 2)

Public summaries of funded Business Interaction Vouchers.

Public summaries of funded Proof of Concept grants.

Publications: a list of papers that resulted from Network funding.

Read about collaborations between academics and Johnson Matthey and Oxford Biotrans

Case studies of completed projects (more will be added as projects complete; clicking on the link will open or download a pdf):

Bioremediation and biorecovery

Sustainable bioleaching of platinum-group metals from spent automotive catalytic converters Case study

Tailoring nickel uptake capacity of willow for phytoremediation, biomass pyrolysis and metal recovery Case study

Microbial recovery of e-tech metals Case study

Enhancing metal uptake and nanoparticle deposition in plants to recover platinum group metals and gold Case study

Selection of rare earth elements through uptake by methylotrophs (SERUM) Case study

Assessing nickel uptake and pyrolysis potential of willow biomass produced from nickel-contaminated soils Case study

Development of a biotechnological protocol for extracting and recovering nickel from pyrrhotite waste and generating an environmentally benign solid residue Case study

Characterising fly ash wastes for phytomining of rare earth elements Case study

Bioflocculants for metal removal and recovery Case study

Biomining of high-value metals from electrical battery waste Case study

Bio-recovery of rare earth elements using Methylotrophs Case study

Bio-hydrogen production from metal-rich sludge return liquors via bio-electrochemical systems: modelling the technology’s impact in the UK water sector Case study

The impact of biological and thermal pre-treatment of sewage sludge on trace element availability for anaerobic digestion Case study

New technologies

Using limpet-derived metal enzymes in sustainable bio-manufacturing Case study

Bioprospecting for new metalloenzymes for the circular economy Case study

Site-specific conjugation of alkaline phosphatase via metal-mediated His-tag complexation for biomanufacturing diagnostic and biotherapeutic reagents Case study

Applying nano-flow cytometry to characterise biomanufactured magnetic fluids Case study

Transcriptomic-based characterisation of gene expression in plant roots in response to a metal nanoparticle barrier Case study

FLAVH2: Establishing the feasibility of a metalloenzyme system for dihydrogen-driven flavin recycling for chemical synthesis Case study

Expanding the biocatalytic hydrogenation toolbox with [FeFe]-hydrogenases Case study

Scaling up [FeFe]-hydrogenases to biocatalysis Case study

Metalloenzymes and biotransformations

Developing a novel chemo-enzymatic catalytic cascade for producing stereoselective high-value chemicals Case study

Conserving the position of rare codons for the optimised production of commercially-important, cofactor-containing enzymes Case study

Enzyme engineering to improve lignin breakdown for the production of fine chemicals or value-added products Case study

Improving ethylene production using non-heme iron-containing ethylene-forming enzymes Case study

Enhancing iron-sulfur cluster functionality in synthetic biology applications Case study

Switching the iron in cytochromes P450 to expand their catalytic repertoire Case study

Understanding the role of metal ions in E. coli across temperature and pH conditions to optimise the manufacturing of next-generation bioproducts Case study

SARS-CoV-2 and COVID-19

Robust SARS-CoV-2 detection for COVID-19 diagnosis: Enhancing loop-mediated isothermal amplification (LAMP) with single-strand DNA binding proteins Case study

Potential anti-viral and therapeutic activities of the enzymatic degradation products of pharmaceutical polysaccharides modulated by metal ions Case study

GLYCOVID-19: Investigating the modulatory effect of metal ions on the interaction of polyanionic heparin with the SARS-CoV-2 spike protein Case study